Today, we'll be discussing CBD, also known as cannabidiol, which has gained popularity in recent years for its potential health benefits.

What is CBD?
CBD is a natural compound found in the Cannabis sativa plant. Unlike its cousin, THC, which is known for its psychoactive effects, CBD does not produce a "high" and is not considered to be addictive. CBD is available in various forms, including oils, capsules, gummies, and topical creams.

What effects does CBD have on the brain/body?
CBD interacts with the body's endocannabinoid system, which helps regulate various physiological processes, including sleep, appetite, mood, and immune function. CBD may also interact with serotonin and GABA receptors, both of which are involved in regulating sleep and anxiety.

Benefits for sleep
Many people use CBD as a sleep aid, claiming that it helps them fall asleep faster and stay asleep longer. CBD may also improve sleep quality by reducing the number of times a person wakes up during the night. Additionally, some research suggests that CBD may be beneficial for people with insomnia or sleep apnea.

Potential side effects
While CBD is generally considered safe, it can cause side effects in some people, including dizziness, nausea, fatigue, and changes in appetite. CBD can also interact with certain medications, so it's important to talk to your doctor before using it as a sleep aid.

Why we didn't include CBD in our Knocked formula
At Knocked, we prioritize using natural and safe ingredients in our products. While CBD has potential benefits for sleep, there is still a lack of high-quality research on its long-term effects, and there are concerns about the purity and potency of some CBD products on the market. For these reasons, we have chosen not to include CBD in our Knocked formula at this time.

CBD is a natural compound that has gained popularity for its potential health benefits, including its ability to improve sleep. While there is still much to learn about its long-term effects, CBD may be a promising sleep aid for some people. However, it's important to talk to your doctor before using CBD as a sleep aid, and to be aware of potential side effects. At Knocked, we will continue to evaluate the research on CBD and other natural ingredients to create safe and effective sleep aids for our customers.

Sources:

1. Babson, K. A., Sottile, J., & Morabito, D. (2017). Cannabis, cannabinoids, and sleep: a review of the literature. Current Psychiatry Reports, 19(4), 23. [https://link.springer.com/article/10.1007%2Fs11920-017-0775-9]

2. Murillo-Rodriguez, E., Millán-Aldaco, D., Palomero-Rivero, M., Mechoulam, R., & Drucker-Colin, R. (2006). Cannabidiol, a constituent of Cannabis sativa, modulates sleep in rats. FEBS Letters, 580(18), 4337-4345. [https://febs.onlinelibrary.wiley.com/doi/abs/10.1016/j.febslet.2006.04.102]

3. Linares, I. M., Guimaraes, F. S., Eckeli, A., Crippa, A. C., Zuardi, A. W., Souza, J. D., ... & Crippa, J. A. (2018). No acute effects of cannabidiol on the sleep-wake cycle of healthy subjects: a randomized, double-blind, placebo-controlled, crossover study. Frontiers in Pharmacology, 9, 315. [https://www.frontiersin.org/articles/10.3389/fphar.2018.00315/full]

4. Iffland, K., & Grotenhermen, F. (2017). An update on safety and side effects of cannabidiol: A review of clinical data and relevant animal studies. Cannabis and Cannabinoid Research, 2(1), 139-154. [https://www.liebertpub.com/doi/10.1089/can.2016.0034]

5. Russo, E. B. (2017). Cannabidiol claims and misconceptions. Trends in Pharmacological Sciences, 38(3), 198-201. [https://www.sciencedirect.com/science/article/pii/S0165614717300057]